first_imgJohnny Wilson, better known as “Jumpin’ Johnny Wilson” was the 1946 Mr. Basketball in the state of Indiana.  The Anderson High School graduate was barely 6 foot tall but he had amazing jumping skills. Recently Anderson honored him with a statue in front of the high school.  Johnny is the oldest, living Mr. Basketball in the state of Indiana.  The 88-year old was one of the first to break the color barrier of “whites only” in basketball.Johnny led Anderson to a state basketball title by scoring 30 of his team’s 67 points in their victory over Ft. Wayne Central in the championship.  He wanted to play basketball at IU, but they had no blacks at that time, so he went to nearby Anderson College.  I was only 7, so I only heard about Johnny Wilson in later years.Wilson is a good friend of Carl Erskine, another Anderson legend, who played baseball with the Brooklyn Dodgers.  Both are still living.  Recently, Johnny Wilson played golf with Glen Butte at the Legends Golf Course in Franklin.Part of this information came from an article in the Indianapolis Star.last_img read more

first_imgMOUNT DESERT — Eighty-three teams traveled to the Mount Desert Island and Ellsworth areas this weekend for this year’s edition of the Great Harbor Shootout.A total of 133 games were played in the tournament, which drew more than 3,000 people to the area. Those games began late Friday afternoon and concluded early Sunday afternoon and were played at Ellsworth-Elementary Middle School, Mount Desert Elementary School, the MDI YMCA, MDI High School, Pemetic Elementary School and Trenton Elementary School.Among local teams, the Down East Family YMCA boys’ squad made it all the way to the junior high school school title game. The team lost 60-56 to Skowhegan in the championship game at MDI High School to finish as runner-up.On the girls’ side, MDI won the high school bracket with a 54-44 victory over Lawrence in Sunday’s championship game at Pemetic Elementary School. Among the Trojans’ other wins en route to the title were a 47-34 win over GSA, a 41-18 win over Caribou, a 45-41 win over Deer Isle-Stonington and a 53-49 win over Calais.This is placeholder textThis is placeholder textThe high school boys’ title went to Hermon, which beat Mount Desert Island in the championship game for the second year in a row to claim its third straight Great Harbor Shootout title. Bangor defeated Southern Aroostook 51-24 to claim the junior high girls’ championship.This year marked the 28th edition of the tournament, which was first held in 1992 as a seven-team competition. The event raises money for the Harbor House Community Center in Southwest Harbor.last_img read more

first_imgMay 14 2018In a new study based on mouse cells internationally leading protein researchers have identified several new potential targets using state-of-the-art technology, many of which could be employed for future treatment of different types of cancers and diseases.Protein researchers from the Novo Nordisk Foundation Center for Protein Research at the University of Copenhagen have used mass spectrometry based proteomics to uncover a number of proteins which could play a critical role propagating signals within cells that can lead to uncontrolled cell growth – one of the hallmarks of cancer.The study, which has been published in the internationally acclaimed scientific journal Cell Reports, was conducted using mouse fibroblast cells.The researchers behind the study believe the results may prove important to the development of new so-called tyrosine phosphatase-inhibiting drugs for patients suffering from different types cancer – for example Leukemia – as well as other types of diseases such as Noonan syndrome.Globally, cancer is one of the leading causes of death according to the World Health Organization. In Denmark one in every three Danes develops cancer at some point in their lives, according to statistics from the Danish Cancer Society.Advanced Cell Communication Can Inhibit Cancer DevelopmentThe researchers focused on the protein communication and signaling that takes place inside the cells. Misregulation of protein signaling often leads to an increase in the production of tumors. By understanding the mechanisms and regulation of these signals, the researchers can specifically target the proteins responsible with drugs.Using mass spectrometry proteomics to analyze the proteins of cells treated with various growth hormones in combination with advanced data analysis, the researchers discovered proteins that manipulate the communication processes inside the cells initiated by cell receptors and thus inhibit the development of cancer.When inhibited the prominent protein tyrosine phosphatase called Shp-2 caught the researchers’ attention.’This in fact leads to the deactivation of a very prominent cell growth pathway, which is the main pathway that people often try to target in cancer cells’, Professor Jesper Velgaard Olsen from the research group explains.Related StoriesResearchers identify potential drug target for multiple cancer typesNew research links “broken heart syndrome” to cancerEmbrace your natural skin tone to prevent skin cancer, say experts100 potential targetsAt the beginning of the study, the researchers knew of a handful of proteins which were regulated by Shp-2. However, using the mass spectrometry analyses the researchers discovered around 100 potential new targets, revealing a far more complexity than previously considered.Now the researchers need to do further studies to determine the role and mechanisms of these proteins. They are already following up on their first results with human cells.’Now we are doing follow-up projects, looking specifically at leukemia, where the cancer cells have mutations in these different receptors which can be regulated by Shp-2′, says Postdoc Tanveer Singh Batth.Cancer patients are often treated with tyrosine kinase inhibitors, which block pathways inside the cells to inhibit tumor growth. However, many develop resistance to current clinical inhibitors thus there is a substantial need for finding new proteins that can be used as drug targets.Personalized MedicineThe researchers’ new discoveries can be used in the development of personalized medicine, where preventive treatments can be targeted at the patients’ personal DNA or protein expression profiles.’It will be a drug that can be used only in a world with personalised medicine, where it will not be given to for example all leukaemia patients, but only to those with mutations in one of the receptor tyrosine kinases where we now know this Shp-2 protein operates’, says Professor Jesper Velgaard Olsen.Personalised medicine is gaining ground in Denmark. In 2016 the Government and the Danish Regions launched a strategy for efforts involving personalised medicine. A main part of the strategy is the establishment of a National Genome Center.Fact Box: The study described in this article was conducted using mouse cells. The researchers use animal models to accumulate more knowledge on the subject, before the test is potentially performed on humans. This means that the same test does not necessarily produce the same results when conducted on humans. The test meets existing laws on animal testing. Far from all studies result in concrete treatment methods, and the process can take several years. Source:http://healthsciences.ku.dk/news/2018/05/researchers-uncover-up-to-100-potential-drug-targets-for-cancer/last_img read more